Drafting a keeper question?

The league allows you to keep 3 players. You can keep 1 keeper for life. The other 2 will very from year to year. The only catch is that they have to be picked after the 5th round. The league is only 3 years old, so players like Vlad, Arod and Pujols are still available. But guys like Teixera, Santana, D.Wright are owned. I took over a very poor team. But my main keeper is Oswalt, along with Mauer and Konerko.

I have the 10th pick in a 10 team serpentine draft. I have the first pick in the 6th round which is the top overall pick for a possible keeper. This could be the most important pick in this years draft for me?

My Question:
Any thoughts, player recommendation??