I had a nice, long, slow drive down the PCH last summer. Enjoyed it greatly.
I've been itching for a trip, my wife isn't... so I might head down that way in the next week or two. Just me and my bike... I'll do the coast down and 5 or 99 back up. When in the Bay Area I try and stay off the highways and do roads like 35, 9 and 1.