Re: You make the call !
Depends on the runners at 1st and 3rd and the pitcher/catcher battery.
If both runners are reasonably fast and the pitcher/catcher combo isn't good at catching base stealers, I'd go for it. The runner on third would draw some attention as a threat for a double-steal, which would increase the chances that the catcher double-clutches or makes a poor throw.
If the runner gets thrown out, the batter still has a chance to score the run with a hit. If the runner makes it safely, a single scores two.
"I prefer books and movies where the conflict isn't of the extreme cannibal apocalypse variety I guess." Redsfaithful