I'm living now where I've always wanted to live: in central Washington, DC. Right now, I can't imagine living anywhere else (although we have discussed Baltimore, but it's only about 30 miles north). Beautiful city, a culture that fits our tastes, great restaurants, plenty of outdoor activities, and sports teams so mind-numbingly awful that I can continue to root for the Ohio teams with a clear conscience. It also helps that I work in a field that, along with the federal government, makes up about 90% of the workforce here.
If we were forced to pack up and head somewhere besides the DC-Baltimore area, San Francisco would top my list, followed by Portland. Boston and Chicago would likely make the short list as well, but my wife despises cold weather and would never agree to it.
Beyond that, there just aren't that many places I am clamoring to live. I don't have a desire to return to Ohio, although I have a great many family members there. Outside of Chicago, the midwest bores me to tears. New York would drive me nuts, LA is too much of a concrete city for me, and just not that culturally interesting. The south is too hot and sticky, and a bit too "laid back" for my tastes. That said, I could probably make do in any of those areas.