I think TC is probably just seeing tent caterpillars, which can do a lot of damage, but which usually don't really harm a tree too severely.Here's some info.
As for Wisteria....it's very hard to eradicate. I had a very mature one in NC. It was on the east side of the house and I found roots on the west side, in the craw space, growing up into the floor joists. These things will drive away with your car if you let them.
However, if you are persistent, you can keep them under control...with a shovel, spade, and maybe a stick of TNT. Get digging and never stop.
I'm in South Carolina right now. If there is a god, he owns a home on Pawleys Island.