Originally Posted by beb30
I just did it recently, and did it directly through mapquest.
Basically you take I 70 up to Indianapolis and then take I 74 to St. Louis its a 5 to 6 hour drive not bad at all.....
I could do this one in my sleep since my wife is from Jefferson City, MO -
You have these reversed. Take I-74 west out of Cincinnati (it ends at I-75 here) to Indy where you pick up I-465 (south or west - you know how those circle freeways are) and connect with I-70 west. You take I-70 all the way into downtown St. Louis. I-74 from the state line is 70 MPH up to Indy, and then I-70 is 70 MPH outside of Indy.
BTW, in my opinion, the Kentucky route is nearly the same distance, but unbelieveably boring and completely lacking in places to stop.