Coming off a 4-2 homestand to open the season, the Reds begin a six-game road trip Tuesday against the Cubs at Wrigley Field.
The Reds were 6-3 last season at Wrigley Field, including victories in five of the last six meetings there.
"I'm looking gorward to it," Reds manager Jerry Narron said of the trip. "We're playing two very good ballclubs in Chicago and St. Louis. They're outstanding."
Bronson Arroyo will make his second start for Cincinnati. For the second time in a week, Arroyo will be opposed by left-hander Glendon Rusch.
In an 8-6 victory over Chicago during his Reds debut at Great American Ball Park, Arroyo allowed five runs (three earned) on six hits. The right-hander did not walk a batter and struck out seven. Of the 26 batters he faced, Arroyo threw 21 first-pitch strikes. He also hit the first homer of his career in his first at-bat.
CIN: RHP Bronson Arroyo (1-0, 4.05 ERA)
The right-hander is 1-3 with a 5.84 ERA in six games lifetime against Chicago. He's 0-2 with a 7.50 ERA at Wrigley.
CHC: LHP Glendon Rusch (0-1, 9.00 ERA)
Gave up four earned runs and six hits over four innings in April 5 loss to the Reds.
Player to watch
Right fielder Austin Kearns has hits in five of his first six games for the Reds.
On the Internet
• Official game notes
• WLW 700-AM
• Wed: Reds (LHP Brandon Claussen, 0-0, 5.40 ERA) at Cubs (RHP Greg Maddux, 1-0, 1.42 ERA) 2:20 p.m. ET
• Thu: Reds (LHP Eric Milton, 1-0, 2.57 ERA) at Cubs (RHP Carlos Zambrano, 0-0, 4.42 ERA) 2:20 p.m. ET
Mark Sheldon is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.