Charles Kuralt, or somebody, said something to the effect of "thanks to the Interstates, you can now drive from coast to coast without seeing anything or meeting anybody."
With the little ones, the loafing and sightseeing on long trips has been reduced, but we'll generally get off I-Whatever for at least a little while. Our road trips are generally between Tennessee and Florida, so we'll side-trip through the Georgia mountains or wait until we get to Florida and cut over to A1A. Or something like that.
Now that I think of it, it's a longstanding habit of mine to not come back exactly the way I went. Even if they're 95% the same roads, I'll vary it just a little. That's usually the case even for trips to the grocery store.