Actually the tower cleared them to the correct rwy 22. They made the wrong turn onto 26. Here's a
link to the transcripts from the tower communications. Note page 5 at 1002:04 the tower clears them to rwy 22. Comair 5191 (noted as COM191 on this transcript) reads back the correct runway (again rwy 22).
I agree that being distracted played some sort of role in this accident (based on the facts available at this time). Bluegrass field isn't all that big so the time to taxi from the gate to the runway isn't very long. In this time the pilots have a myrid of check lists and other duties to perform. Yet, the captain especially kept talking about non-flight related subjects which can't do much for cockpit discipline.
The first officer doesn't say much in the begining and then eventually starts chiming in. So you have a first officer who is now chatting and mixing in checklists (ie take off preperations) as he is taxing towards the runway and subsequent take off. And you have a captain who is a chatterbox and seems more interested in what is going with staffing issues instead of assisting the first officer.
Mix in a dark rainy morning, a confusing taxiway scheme and incorrect situational picture reinforced by the missing rwy lights and you have an accident. Unfortunatly, in the case, 49 people paid the price.
I don't know if I'd call the pilots stooges. Accidents caused by pilot error (and there has been no offical determination as to the cause of this accident) tend to leave the impression that the pilots were bumbling idiots. It doesn't paint a picture of the hundreds of other flights where they may have flown competently. It may be they let their guard down this one time (I doubt it, but it's possible) and it bit them in the keister.
Then again, poor airmanship has a way of catching up with people.