Leno's last show as host of The Tonight Show is set for Friday, May 29, with Conan taking over the show Monday, June 1. Leno then will take his act to the 10:00pm time slot weeknights on NBC. It will be interesting to see how this goes. One thing's for sure: late night television will get its biggest shakeup since 1992, when Johnny Carson retired and David Letterman left NBC.