One guy did it, every game, for an entire season:
Here's a link to his spreadsheet, detailing every bet placed and his running +/- total for the year: http://www.tinyurl.com/piratebetEarly in the season, we examined one Bucs fan's foolproof strategy of always betting against the Pirates. Turns out, they were even worse than Vegas knew. A 9.98 percent ROI was his reward.
All totaled, the Bucs made this guy a $324.34 profit, but I'm not sure that's worth the soul-crushing nature of having to check the Pirates box score every day for a full season.