In Perea's case, heck yes in some cases.
I witnessed the Northwestern debacle firsthand, and while Howard entered the game and played meaningful minutes shutting down Drew Crawford in the process and allowing IU to get back in the game, that particular game against a much smaller opponent just screamed play Noah and HMP together.
The recent Duke/Syracuse game illustrated one textbook method of attacking the 2/3 zone and the same principles apply to attacking a packing-it-in defense....High - Low sets, which I've already outlined in a previous post. Also, by having both NV and HMP on the floor at same time, you virtually guarantee a weak side shot-blocking threat and on an offensively challenged team that needs to create offense from defense, improving interior defense-- and defense as whole -- even slightly could go a long way.