Luis Castillo needed 32 pitches to work his way through the first inning and gave up two runs.
From there, Castillo settled in. He struck out the side in the third — Rafael Ortega, Happ and Suzuki, the heart of the Cubs order.
After the first inning, only two runners reached base through the fifth inning, but Castillo was pulled after five innings and 94 pitches.
The much-maligned bullpen kept the Cubs’ bats quiet — runless innings from Tony Santillan, Alexis Diaz and Art Warren before Strickland made is shaky save in the ninth.
The ninth inning was a finger-biter for the Reds. They led 4-2 with one out when Strickland hit Wisdom. He then walked Alfonso Rivas on a full count, putting the potential tying runs on base.
Pinch-hitter Willson Contreras drove one to deep right center, and Nick Senzel speedily chased it down with a leap against the wall, one of three ultra-special defensive plays Senzel made on this night.
Pinch-hitter Nicol Hoerner blooped a single to right, scoring Wisdom to make it 4-3 and put the tying run on third.
Strickland ended it by striking out Christopher Morel. It was Strickland’s first save in three years.